Natural treatment for cholesterol | FunctionFitness
Fasting triglycerides, high-density lipoprotein, a...[Circulation. 1997] - PubMed Result
...the ratio of triglycerides to HDL was a strong predictor of myocardial infarction (RR in the highest compared with the lowest quartile=16.0; 95% CI=7.7 to 33.1; P for trend <.001). CONCLUSIONS: Our data indicate that fasting triglycerides, as a marker for triglyceride-rich lipoproteins, may provide valuable information about the atherogenic potential of the lipoprotein profile, particularly when considered in context of HDL levels.
Triglycerides and coronary risk. [Curr Cardiol Rep. 1999] - PubMed Result
Limited data from clinical trials suggest that intervention with agents that lower triglycerides and raise HDL tend to reduce event rates among those with elevated and normal LDL levels.

Plavix: Winners and Losers -- Seeking Alpha
30% of patients taking Plavix do not metabolize the drug because of genetic variation thus receiving little or no benefit.
Framingham and NCEP risk scores correlate poorly with plaque burden on CT
Framingham predicts the risk of a coronary event only 60% to 65% of the time, he said. "When you turn around and you try to use that kind of epidemiological data to make a clinical decision in the doctor's office, it falls apart. Statistically, the discrimination that you can make is just not strong enough, because there will be a lot of people who have a low Framingham risk who have a lot of atherosclerotic plaque, and a lot of people with high risk, by Framingham score, with no plaque."

BINGO! Exactly right and exactly what I've been saying to my docs for months now. Epi studies are next to worthless for clinical decisions. Epi studies should guide clinical research, NOT clinical treatment. People with low cholesterol, high cholesterol, and everything in-between have heart disease. If the model doesn't fit the observations (in this case risk profile) doesn't fit the observations, the model needs to be replaced with a new model that better matches observations. Promising models include the cholesterol molecular size, lipoprotein (a), vitamin C, etc. (See Cholesterol Levels NOT Highly Correlated with Heart Disease.)
Researchers make synthetic HDL cholesterol -study | Reuters
U.S. researchers have developed a synthetic form of good cholesterol known as HDL they hope will be able to keep levels of bad cholesterol in check.

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